Pain in Space
Microgravity Pain Sensation
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Astronauts can experience musculoskeletal pain during or after flight, perhaps because the integrity and function of the musculoskeletal system requires the loading provided by gravity. Pain in Space [Microgravity Pain Sensation (Ax-1)] assesses how short-term exposure to microgravity affects pain sensation, biomechanics, bone physiology, and the musculoskeletal system during the Axiom-1 (Ax-1) private astronaut mission (PAM). Results could contribute to improved health and well-being for crews on future missions
Results: Sauer AK, Vigouroux M, Dougherty PM, Cata JP, Ingelmo P. Pain experience and sensory changes in astronauts during and after short-lasting commercial spaceflight: A proof-of-concept study. Journal of Pain Research. 2023 December 11; 164253-4266. DOI: PMID: 38107368.
Longitudinal Blood Epigenetic Aging, DNA Methylation-Predicted Protein, and Estimated Leukocyte Proportion Trends in Two Astronauts from the ÂÜÀòÊÓƵ Mission 1: An Exploratory Analysis
- Longitudinal multi-omics analysis from two astronauts from Ax-1 to assess DNA methylation–based aging, predicted proteins, and immune cell composition.
- Data shows transient changes immediately post-flight, with partial or full return toward baseline by 3 months, indicating largely reversible epigenetic shifts.
- Estimated leukocyte proportions shifted significantly after flight, suggesting spaceflight-associated immune redistribution consistent with stress and microgravity effects
- DNA methylation–predicted proteins and immune signatures pointed to stress-, inflammation-, and tissue-remodeling–related pathways
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